Research - Vitamin E for Dogs and Cats - Bonnie and Clyde Pet Goods

Research - Vitamin E for Dogs and Cats


The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs

"These data suggest that although a ratio of dietary (n-6) to (n-3) fatty acids of 1.4:1 depresses the cell-mediated immune response and PGE2 production, it increases lipid peroxidation and lowers vitamin E concentration."

NOTE: This is why Bonnie and Clyde Pet Goods has added a nutritionally significant amount of natural source vitamin E to our Wild Omega-3 product.

Modulation of inflammation and oxidative stress in canine chondrocytes

"Use of antioxidants, on the other hand, may be helpful in the treatment of arthritic dogs."

NOTE: This was an in-vitro study.

Effect of increasing dietary antioxidants on concentrations of vitamin E and total alkenals in serum of dogs and cats

"Increasing levels of dietary vitamin E in dog and cat foods caused significant increases in serum vitamin E levels compared with baseline values … normal dogs and cats experience oxidative damage and that increased dietary levels of antioxidants may decrease in vivo measures of oxidative damage."


Anti-inflammatory response of dietary vitamin E and its effects on pain and joint structures during early stages of surgically induced osteoarthritis in dogs

" … dogs with OA using a supplement with a high dose of vitamin E showed a reduction in inflammation joint markers and histological expression, as well as a trend to improving signs of pain."

Skin and Coat

Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers

"Significantly higher plasma levels of vitamin E and TAC were observed in the vitamin E group than in the placebo group. CADESI-03* scores determined throughout the treatment in the vitamin E group were significantly lower than in the placebo group. The findings of this study support the supplementation of vitamin E in dogs with atopic dermatitis."

*CADESI-03: Canine Atopic Dermatitis Extent and Severity Index

Effects of Serum Vitamin E Levels on Skin Vitamin E Levels in Dogs and Cats

"Vitamin E is a chain-breaking antioxidant that prevents the propagation of free-radical reactions … Tissues depend on plasma vitamin E levels. Vitamin E is a significant constituent of sebum and is continuously secreted for delivery to upper layers of the skin ... Vitamin E protects against UV-induced skin photodamage through a combination of antioxidant and UV-absorptive properties ... increasing amounts of dietary vitamin E in foods for dogs and cats increases serum and skin concentrations of vitamin E and decreases serum levels of some of the biomarkers associated with oxidative stress."

Brain & Steatitis (Yellow Fat Disease)

The protective effect of vitamin E on cerebral ischemia

"In the groups given vitamin E, the recovery time was significantly shortened … These experimental results indicate that the administration of vitamin E is effective in protecting the brain from cerebral ischemia."

NOTE: The vitamin E was administered intravenously.

Vitamin E Deficiency in Cats (1962)

"Purified diets containing varying levels of vitamin E, and with and without tuna oil as a source of highly unsaturated fatty acids, were fed to cats for periods up to 13.5 months. Steatitis was observed in cats receiving diets deficient in vitamin E and containing tuna oil ... Vitamin E provided complete protection against steatitis in these experiments."